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KMID : 0438219780150010053
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Korea University Medical Journal
1978 Volume.15 No. 1 p.53 ~ p.62
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Influence of Ca concentration on responses of isolated organs of normal and reserpinized rabbits to catecholamines
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Abstract
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Dahlla et al. reported that increasing´the concentration of Ca in the bathing medium from 0.625 mM to 2.5 mM decreased response of rat ventricle to norepinephrine, but Sullivan et al, showed that variation. of Ca concentration between 0.15 mM and 2.4 mM had no significant effect on response of rabbit aortic s rips to norepinephrine.
In order to investigate the influence of Ca concentration on responses of the isolated organs of normal and reserpini 4rabbits ib-catecholamines, author observed the contractile responses of the isolated atria, aortic_.atrips, splenic-capsules and vas deferenses of normal -and´reserpinized rabbits to epinephrine _and;.norepinephrine -in Locke-Ringer bathing medium containing 1. 2 mM -and 2.4 mM Ca ;respectively_
results obtg nej were _summarized as follows:-.
t~ In~_1.2 mM `Ca.-Locke-Ringer _ medium than normal Locke-Ringer medium (containing 14 mM J. ACa).,- gponses-oUisolated atria and aortic strips of-normal rabbits to both epinephrine and. nore-3pinephrine were -morez ;significantly increasedi and responses of vas deferenses not´ significantly .increased,. but responses of splenic capsules rather decreased.
2. In normal Locke=Ringer medium, responses of isolated atria, aortic strips. and vas deferenses to both catecholamines were significantly increased by reserpine pretreatment, but by decrease of calcium concentration in Locke-Ringer medium to 1.2 mM, the increase of the responses by reserpine pretreatment were mot affected.
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